AECOS Corneal Cross-Linking Clinical Trial

AECOS® (American-European Congress of Ophthalmic Surgery) was pleased to sponsor a leading accelerated cross-linking study, ACOS-KXL-001, in which 83 clinical sites offered accelerated cross-linking throughout the US. AECOS received approval from the FDA to initiate the phase 3, multicenter, randomized, controlled evaluation of the safety and efficacy of corneal collagen cross-linking in eyes with keratoconus or corneal ectasia after refractive surgery. The study exclusively utilized Avedro’s riboflavin and KXL system for accelerated cross-linking.  Patients with keratoconus and corneal ectasia were recruited nationwide to evaluate and compare the safety and efficacy of three treatment regimens for corneal collagen cross-linking performed with Avedro’s riboflavin and KXL System for reducing corneal curvature. Corneal collagen cross-linking has been commonly used as the first-line method to restore corneal stability in keratoconic and corneal ectatic eyes in Europe and throughout the world for many years.  The AECOS study was concluded in June 2016 with very favorable results.  It is the largest body of corneal cross-linking data in the world.

Principal Investigators: AECOS Corneal Cross-Linking Clinical Sites:

Last Name First Name Practice Name
Aran Alberto The Laser Center of Coral Gables
Ashford William Eye Surgery and Laser Center
Ayres Brandon Ophthalmic Partners of PA, P.C.
Bagan Steven Bagan Strinden Vision
Batra Nicholas Batra Vision Medical Group
Beckman Kenneth Comprehensive Eye Care of Central Ohio
Boland Thomas Northeastern Eye Institute
Braverman Stanley Braverman Eye Center
Bucci Frank A. Bucci Laser Vision Institute
Chamberlain Winston Casey Eye Institute/OHSU
Chu Y. Ralph Chu Vision Institute
Chung Gary Evergreen Eye Center
Clinch Thomas Eye Doctors of Washington
Dell Steven J. Dell Laser Consultants
Desai Neel The Eye Institute of West Florida
Doe Erin Berkeley Eye Center
Dunn Steven Michigan Cornea Consultants, PC
Ellis Dean Kansas LasikPlus, P.A.
Fintelmann Robert Barnet Dulaney Perkins Eye Center
Fram Nicole Advanced Vision Care
Gangadhar Dasa Grene Vision Group
Gira Joseph P. Ophthalmology Consultants
Gordon Richard Ramapo Ophthalmology Associates, LLP
Grace Colleen Henry Ford Health System
Greenberg Jason LasikPlus Vision Center
Greiner Mark University of Iowa Hospitals and Clinics
Groden Lewis LCA-Vision Inc.
Herschel Mark Herschel Lasik
Himmel Kenneth Eye Associates of New Mexico
Ing Jeffrey Delta Eye Medical Group
Iuorno Joseph D. Commonwealth Eye Associates
Jain Vivek Beach Eye Care
Jones Michael Paul Illinois Eye Surgeons
Khachikian Stephen Black Hills Regional Eye Institute
Kuck Paul Gundersen Clinic, Ltd.
Kugler Lance Kugler Vision, PC
Labor Phillips Eye Consultants of Texas
Lehmann James Focal Point Vision
Liang Keith Center for Sight
Loden James Loden Vision Centers
Manche Edward Stanford University School of Medicine
Melki Samir Boston Eye Group
Meskin Seth Eye Physicians and Surgeons, PC
Mian Shahzad University of Michigan
Miedziak Anita Princeton Eye Group
Mishra Gautam Schein Ernst Eye Associates
Moshirfar Majid The Moran Eye Center, University of Utah
Newman Leonard Newman Lasik Centers
Orlin Stephen E. Scheie Eye Institute, Penn School of Medicine
Paglen Patrick Kaiser Permanente
Parker John John Parker, MD (private office)
Pepose Jay Pepose Vision Institute / Lifelong Vision Foundation
Petashnick Daniel Manchester Ophthalmology
Pramanik Sudeep Mid-Atlantic Cornea Consultants
Raizman Michael Ophthalmic Consultants of Boston
Ramirez Ruben Buena Vista Eyecare
Rapuano Christopher Corneal Associates, PC at Wills Eye Institute
Richheimer William Mile High Corneal Specialists, PC
Rivera Lilia Lilia Rivera, MD
Rivera Robert P. Hoopes Vision
Rosenfeld Steven Delray Eye Associates, PA
Shah Pulin Ochsner Medical Center
Shah Ravindra A. Eyecare Medical Group
Sheppard John Virginia Eye Consultants
Shih Carolyn North Shore LIJ Health Systems
Sierra Patricia Grutzmacher, Lewis and Sierra
Silk Wesam Silk Vision & Surgical Center
Slade Stephen Slade and Baker Vision Center
Smith Byron The Eye Clinic Surgicenter
Solomon Jonathan Solomon Eye Physicians & Surgeons
Stevens Garth Eye Care Center of Virginia
Stone Donald Dean McGee Eye Institute
Straiko Michael Devers Eye Institute
Sutton Gregory Eye Surgical Associates
Thompson Vance Vance Thompson Vision
Verdier David Verdier Eye Center, P.L.C
Vukich John Davis Duehr Dean Eye Care
Wang Ming Xu Wang Vision Institute
Weisenthal Robert CNY Eye Care
Wellish Kent Wellish Vision Institute
Wolsey Darcy The Eye Institute of Utah
Woodcock Michael Carolina Vision Center
Wright Paul Wright Vision Center